Does a Light Therapy panel make you perspire?

This is dependent on the individual. It also depends on how long the session is. Some might feel some perspiration where light is directed. It is mainly the Near Infrared (NIR) in the Red Light Therapy that generates warmth. The more Near Infrared light there is, the more warmth will be generated. You can deselect the NIR on many panels, but you will lose some of the effect.